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8 Colorimetry Principle: The sample is extracted with water, and proteins are precipitated with perchloric acid and then filtered

In humans, CYP3A is readily induced by xenobiotics, is activated by CYP3A inducers, and leads to activation of PXR (Kliewer 2003

Lower melatonin doses (1.5 mg/kg/day) in a mouse model of AD (Tg2576) showed no significant modification of brain APP immunoreactivity compared to non-treated animals [165], emphasizing the need to determine efficacious doses